When faced with multiple assailants, you should use a circular or semicircular spray pattern technique that provides a protective barrier. If the assailants are in front of you, spray the one nearest you directly. His sudden reaction may stop the others when they see the agony he's going through. As with a single assailant, immediately begin retreating or backing up, never taking your eyes off the assailants, remaining ready to spray anyone else foolish enough to pursue. Retreat and escape to safety as previously described.
Multiple assailants will often travel and strike in packs, for protection and dominance. Usually when one or two of them are stopped, the rest will stop as well. If multiple assailants keep coming toward you, even after stopping one of them, put out a 180 degree arc of spray to your front while continuing to back up. You must fight the natural urge to turn your back on the assailants and run. You cannot disable them as well, or as effectively, if you're running away. The idea is to force the assailants through the spray to get to you. Keep in mind this defense works best at a range of six to eight feet. Any shorter distance and they're too close. The successful use of the 180 degree spray tactic also depends on the type and range of your spray. Test spray your unit to determine its range and spray pattern. Again, don't wave the spray around like a fire hose. Lay down a solid, continuous barrier of protection quickly but thoroughly.
There's an exception to the single and multiple assailant tactics just described. If your assailant(s) attack you at a run, your first, and best instinct, is to run as well. But while you're running, pull the spray, aim it behind you, and shoot. This tactic again forces the assailant(s) through the spray to get to you. Use this only as an emergency measure, however, and only spray when you know the assailant(s) are in the effective range of your spray, usually 8 to 10 feet. Otherwise you're simply wasting the spray.